單抗144734-HRP中英文實(shí)驗(yàn)說(shuō)明

2019年3月，蘇州螞蟻淘生物科技有限公司正式獲得USBIo中國(guó)大陸區(qū)總代理*。USBIo全稱United States BIOLOGical，也簡(jiǎn)稱為USBIological。位于麻省斯萬(wàn)普斯科特(Swampscott, MA)。是生物化學(xué)和生物學(xué)試劑的專業(yè)生產(chǎn)商，產(chǎn)品服務(wù)于免疫學(xué)，分子生物學(xué)，分子遺傳學(xué)，體外診斷，組織培養(yǎng)等科研領(lǐng)域。產(chǎn)品精確度高，質(zhì)量穩(wěn)定，產(chǎn)品數(shù)量巨大，提供70,000多種抗體、抗原和生化試劑等。

主要產(chǎn)品種類(lèi)包括：抗體、生化試劑、基因克隆相關(guān)產(chǎn)品、培養(yǎng)基、生長(zhǎng)因子等細(xì)胞因子、分子生物學(xué)試劑。

uSBIo品牌單抗144734-HRP實(shí)驗(yàn)說(shuō)明

IL-17（白細(xì)胞介素-17），初由Rouvier等人鑒定為來(lái)自嚙齒動(dòng)物T細(xì)胞雜交瘤的轉(zhuǎn)錄物。 1993年，是一組稱為IL-17家族的細(xì)胞因子的創(chuàng)始成員。在嚙齒動(dòng)物中稱為CTLA8，IL-17顯示出與由T-淋巴細(xì)菌性rhADInovirus皰疹病毒saimiri的開(kāi)放閱讀框編碼的病毒IL-17高度同源。小鼠IL-17與大鼠具有85％的氨基酸序列同源性。白細(xì)胞介素17是一種細(xì)胞因子，通過(guò)增加各種組織中的趨化因子產(chǎn)生，將單核細(xì)胞和嗜中性粒細(xì)胞募集到炎癥部位，作為延遲型反應(yīng)的有效介質(zhì)，類(lèi)似于干擾素γ。 IL-17由T輔助細(xì)胞產(chǎn)生并由IL-23誘導(dǎo)，其導(dǎo)致延遲型反應(yīng)中的破壞性組織損傷。白細(xì)胞介素17作為一個(gè)家族起著促炎細(xì)胞因子的作用，它可以通過(guò)細(xì)胞外病原體對(duì)免疫系統(tǒng)的侵襲作出反應(yīng)，并誘導(dǎo)病原體細(xì)胞基質(zhì)的破壞。白細(xì)胞介素17與腫瘤壞死因子和白細(xì)胞介素-1協(xié)同作用。為了引發(fā)其功能，IL-17結(jié)合稱為IL-17R的I型細(xì)胞表面受體，其中存在至少三種變體IL17RA，IL17RB和IL17RC。

單抗144734-HRP中英文實(shí)驗(yàn)說(shuō)明

IL-17(Interleukin-17), originally identified as a transcript from a rodent T-cell hybridoma by Rouvier et al. in 1993, is the founding member of a group of cytokines called the IL-17 family. Known as CTLA8 in rodents, IL-17 shows high homology to viral IL-17 encoded by an open reADIng frame of the T-lymphotropic rhADInovirus Herpesvirus saimiri. Mouse IL-17 shares 85% amino acid sequence homology with rat. Interleukin 17 is a cytokine that acts as a potent mediator in delayed-type reactions by increasing chemokine production in various tissues to recruit monocytes and neutrophils to the site of inflammation, similar to Interferon gamma. IL-17 is produced by T-helper cells and is induced by IL–23 which results in destructive tissue damage in delayed-type reactions. Interleukin 17 as a family functions as a proinflammatory cytokine that responds to the invasion of the immune system by extracellular pathogens and induces destruction of the pathogen’s cellular matrix. Interleukin 17 acts synergistically with tumor necrosis factor and interleukin-1. To elicit its functions, IL-17 binds to a type I cell surface receptor called IL-17R of which there are at least three variants IL17RA, IL17RB, and IL17RC.

UniProt Number

Q62386

Gene ID

IL17A

Applications

Suitable for use in ELISA, Western Blot.

Recommended Dilution

Optimal dilutions to be determined by the researcher.

Storage and Handling

Store at -20?C for one year. After reconstitution, store at 4?C for one month. Can also be aliquoted and stored frozen at -20?C for long term. Avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Note: Applications are based on unconjugated antibody.

Immunogen

E. coli-derived mouse IL-17 recombinant protein (Position: A26-A158).

Form

Supplied as a liquid in PBS, pH 7.2. Labeled with horserADIsh peroxidase (HRP).

Purity

Purified by immunoaffinity chromatography.

Specificity

Recognizes mouse IL-17/IL-17A. No crossreactivity with other proteins.